A NEW LOOK AT THE OLD PROBLEM OF NON-ALCOHOLIC LIVER DISEASE AS A PATHOLOGY ASSOCIATED WITH CHANGES IN THE MICROBIOTA
DOI:
https://doi.org/10.32782/2077-6594.1.1.2021.227165Keywords:
non-alcoholic fatty liver disease, intestinal microbiota, human microbiomeAbstract
Purpose. To analyze the relationship between non-alcoholic fatty liver disease and changes in the intestinal microbiota.
Materials and methods. The publications of domestic and foreign editions in the databases of the United European Gastroenterology (UEG) Journal, PubMed, MEDLINE, Web of Science were processed and analyzed.
Results. In recent years, non-alcoholic fatty liver disease has taken an important place among diseases in gastroenterology. During this time, more and more data appear on the interdependence of changes in the human intestinal microbiome and the development of metabolic diseases, including NAFLD. Many modern studies have indeed found some relationship, but the issue remains unclear.
Conclusions. To better understand the strategies for treating pathologies, it is necessary to delve into the study of etiological factors, from the fact that NAFLD cannot be considered a pathology that has been sufficiently studied from the outside, both treatment and etiology.
References
Broussard, J.L.; Devkota, S. The changing microbial landscape of Western society: Diet, dwellings and discordance. Mol. Metab. 2016, 5, 737–742, doi:10.1016/j.molmet.2016.07.007.
Brown CT, Sharon I, Thomas BC, Castelle CJ, Morowitz MJ, Banfeld JF (2013) Genome resolved analysis of a premature infant gut microbial community reveals a Varibaculum cambriense genome and a shift towards fermentation-based metabolism during the third week of life. Microbiome 1(1):30. https ://doi.org/10.1186/2049-2618-1-30.
Clemente JC, Ursell LK, Parfrey LW, Knight R (2012) The impact of the gut microbiota on human health: an integrative view. Cell 148(6):1258–1270.
Dao M.C., Everard A., Aron-Wisnewsky J., Sokolovska N., Prifti E., Verger E.O. et al. (2016). Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut., vol. 65, pp. 426–436, DOI 10.1136/gutjnl-2014-308778.
David, L.A.; Maurice, C.F.; Carmody, R.N.; Gootenberg, D.; Button, J.E.; Wolfe, B.E.; Ling, A.V.; Devlin, A.S.; Varma, Y.; Fischbach, M.A.; et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014, 505, 559–563, doi:10.1038/nature12820.
Dethlefsen L, Huse S, Sogin ML, Relman DA (2008) The pervasive efects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 6(11):e280.
Drenick EJ, Fisler J, Johnson D (1982) Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition. Gastroenterology 82(3):535–548.
Gillespie JJ, Wattam AR, Cammer SA, Gabbard JL, Shukla MP, Dalay O, Driscoll T, Hix D, Mane SP, Mao C, Nordberg EK, Scott M, Schulman JR, Snyder EE, Sullivan DE, Wang C, Warren A, Williams KP, Xue T, Yoo HS, Zhang C, Zhang Y, Will R, Kenyon RW, Sobral BW (2011) PATRIC: the comprehensive bacterial bioinformatics resource with a focus on human pathogenic species. Infect Immun 79(11):4286–4298.
Huttenhower C, Gevers D, Knight R, Abubucker S, Badger JH, Chinwalla AT, Creasy HH, Earl AM, FitzGerald MG, Fulton RS, Giglio MG (2012) Structure, function and diversity of the healthy human microbiome. Nature 486(7402):207–214. https ://doi.org/10.1038/nature11234.
Koeth R.A., Wang Z., Levison B.S., Buffa J.A., Org E., Sheehy B.T. et al. (2013). Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med., vol. 19, pp. 576–585, DOI 10.1038/nm.3145.
Kovacs A, Ben-Jacob N, Tayem H, Halperin E, Iraqi FA, Gophna U (2011) Genotype is a stronger determinant than sex of the mouse gut microbiota. Microb Ecol 61(2):423–428.
Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444(7122):1022–1023.
Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE (2017) Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 25(5):1054–1062.e1055.
Macpherson AJ, de Aguero MG, Ganal-Vonarburg SC (2017) How nutrition and the maternal microbiota shape the neonatal immune system. Nat Rev Immunol 17(8):508–517.
Madrid AM, Hurtado C, Venegas M, Cumsille F, Deflippi C (2001) Long-Term treatment with cisapride and antibiotics in liver cirrhosis: efect on small intestinal motility, bacterial overgrowth, and liver function. Am J Gastroenterol 96(4):1251–1255.
Mouzaki M, Comelli EM, Arendt BM, Bonengel J, Fung SK, Fischer SE, McGilvray ID, Allard JP (2013) Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology (Baltimore, MD) 58(1):120–127.
Muegge, B.D.; Kuczynski, J.; Knights, D.; Clemente, J.C.; González, A.; Fontana, L.; Henrissat, B.; Knight, R.; Gordon, J.I. Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science 2011, 332, 970–974, doi:10.1126/science.1198719.
Ridaura V.K., Faith J.J., Rey F.E., Cheng J., Duncan A.E., Kau A.L. et al. (2013). Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, vol. 341 (6150), pp. 1241214,DOI 10.1126/science.1241214.
Shankar, V.; Gouda, M.; Moncivaiz, J.; Gordon, A.; Reo, N.V.; Hussein, L.; Paliy, O. Differences in gut metabolites and microbial composition and functions between Egyptian and U.S. children are consistent with their diets. mSystems 2017, 2, e00169-16.
Sleisenger MH, Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management, 9th ed. Philadelphia, PA: Saunders/Elsevier, 2010.
Swidsinski A, Loening-Baucke V, Lochs H, Hale LP (2005) Spatial organization of bacterial fora in normal and infamed intestine: a fuorescence in situ hybridization study in mice. World J Gastroenterol 11(8):1131–1140.
Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI (2009) The efect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 1(6):6ra14. https://doi.org/10.1126/scitranslm ed.3000322.
Voigt, R.M.; Summa, K.C.; Forsyth, C.B.; Green, S.J.; Engen, P.; Naqib, A.; Vitaterna, M.H.; Turek, F.W.; Keshavarzian, A. The circadian clock mutation promotes intestinal dysbiosis. Alcohol.-Clin. Exp. Res. 2016, 40, 335–347.
Wang B, Jiang X, Cao M, Ge J, Bao Q, Tang L, Chen Y, Li L (2016) Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease. Sci Rep 6:32002.
Wong VW, Tse CH, Lam TT, Wong GL, Chim AM, Chu WC, Yeung DK, Law PT, Kwan HS, Yu J, Sung JJ, Chan HL (2013) Molecular characterization of the fecal microbiota in patients with nonalcoholic steatohepatitis – a longitudinal study. PLoS One 8(4):e62885.
Yari Z, Rahimlou M, Eslamparast T, Ebrahimi-Daryani N, Poustchi H, Hekmatdoost A (2016) Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. Int J Food Sci Nutr 67(4):461–469.
Yatsunenko T, Rey FE, Manary MJ, Trehan I, DominguezBello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI (2012) Human gut microbiome viewed across age and geography. Nature 486(7402): 222–227.
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2016) Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology (Baltimore, MD) 64(1):73–84.
Zhu L, Baker SS, Gill C, Liu W, Alkhouri R, Baker RD, Gill SR (2013) Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology (Baltimore, MD) 57(2):601–609.
