FACTORS AFFECTING THE FORMATION OF CHRONIC PANCREATITIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN THE TRANSCARPATHIAN REGION
DOI:
https://doi.org/10.32782/2077-6594.4.0.2020.220394Keywords:
chronic pancreatitis, diabetes mellitus, external factorsAbstract
Chronic pancreatitis (CP) is one of the most common gastrointestinal diseases, accounting for about 8–10% of all digestive diseases. It should be noted that the vast majority of patients with CP (approximately 25% of patients) 10 years after the diagnosis of CP are forced to leave their professional activities or become disabled.
The aim of the study was to determine the factors influencing the formation of CP in patients with diabetes mellitus (DM) type 2 in the Transcarpathian region.
Materials and methods. 64 patients with CP and DM type 2 were examined. Patients with CP were divided into 2 groups: the first group included 62 patients with type 1 diabetes, and the second group consisted of 64 patients with type 2 diabetes. All examined patients underwent general clinical studies.
Results. Among those examined for CP and DM type 2, urban residents predominated (59.4% of patients), while rural residents accounted for 40.6% – p<0.05. It was established that patients with CP and DM type 2, persons with higher education and secondary special education are determined with almost the same frequency (40.6% and 42.2%, respectively). A high percentage of patients with CP and DM type 2 were found? who don’t have a permanent job (34.4%). Among residents of rural areas of Transcarpathian region was preveled patients with CP and DM type 2 with overweight (38.5%) and normal weight (23.1%) – p<0.05, and among patients living in cities of Transcarpathian region was dominated patients with obese of the I degree (42.1% – p<0.01), obesity II degree and overweight (21.1%).
Conclusions. At patients with CP and DM type 2 more often occurs in subjects who don’t have a permanent job, but have higher education. CP in DM type 2 is more often found in subjects living in the cities of the Transcarpathian region, who are overweight and obese of varying severity.
References
Hristich TM, Hontsariuk DO. Etiological factors which from the chronical pancreatitis. Zdobutki klinichnoji I eksperimentalnoji medicine. 2018; 3: 20-27. (in Ukrainian) DOI 10.11603/1811-2471.2018.v0.i3.9221.
Larin AS, Tkach SM. Phatogenetocheskaja rol kisechnogo disbioza v razvitii ozhirenia, insulinorezistentnosti I sacharnogo diabeta 2 tipa. Health of Ukraine. Thematic number. Gastroenterology. Hepatology. Coloproctology. 2016; 2 (40): 20-21. (in Russian).
Zhuravlyova LV, Shekhovtsova YuO. The Diabetes Mellitus Type 2 and Chronic Pancreatitis: One Gland – Two Problems. Drugs of Ukraine. 2014. 9 (185); 11-14. (in Ukrainian).
Singh VK, Haupt ME, Geller DE, Hall JA, Quintana Diez PM Less common etiologies of exocrine pancreatic insufficiency. World J Gastroenterol. 2017; № 23(39): 7059-7076.
Raksha NG, Halenova TI, Vovk TB, Sukhodolia SA, Beregova TV, Ostapchenko LI. Proteolitic imbalance as a key factor of the development of chronic pancreatitis with and without type 1 diabetes mellitus. Visnik problem biologii i medicine. 2019; 3 (152): 186-191. (in Ukrainian) DOI 10.29254/2077-4214-2019-3-152-186-191.
Johnston PC, Thompson J, Mckee A, Hamill C, Wallace I Diabetes and Chronic Pancreatitis: Considerations in the Holistic Management of an Often Neglected Disease / Journal of Diabetes Research. 2019; Article ID 2487804 https://doi.org/10.1155/2019/2487804
Babinec LS, Nazarchuk NV, Bocjuk Nye et al. Trophological status of patients with chronic pancreatitis of bolliary genesis. Achievements of Clinical and Experimental Medicine. 2015; 1. 142-143. (in Ukrainian).
WHO: Global Database on Body Mass Index. Available from: http://apps.who.int/bmi/index.jsp? introPage=intro_3.html.
Hobzej MK, Guljchij MV, Stepanenko AV et al. Type 2 Diabetes Mellitus. Unified clinical protocol for primary and secondary (specialized) medical care. Kijiv; 2012. 118 p. (in Ukrainian). http://ukrgastro.com.ua/klinichni-protokoli-ta-nastanovi.
Hobzej MK, Matyuha LF, Netjazhenko VZ et al. Type 2 Diabetes Mellitus. Adapted clinical guideline based on evidence. Kijiv; 2012. 343 p. (in Ukrainian). http://ukrgastro.com.ua/klinichni-protokoli-ta-nastanovi.
