DIAGNOSTIC VALUE OF HEART-TYPE FATTY ACID BINDING PROTEIN IN GROUP OF PATIENTS WITH STEMI AT THE TIME OF APPLICATION FOR MEDICAL CARE
DOI:
https://doi.org/10.24144/2077-6594.2.2020.201476Keywords:
heart-type fatty acid binding protein, troponin I, acute myocardial infarction, NSTEMIAbstract
The aim of the study – to determine the diagnostic value of heart-type fatty acid binding protein in group of patients with STEMI.
Materials and methods. We examined 280 patients with STEMI, 91 patients with NSTEMI, 76 with stable angina pectoris. Blood samples were taken from all patients at the first contact to determine troponin I, a heart-type fatty acid-binding protein and CPK-MB. Patients with STEMI were divided into three subgroups: the first – up to 3 hours from the onset of symptoms, the second – from 3 to 6, the third from 6 to 12. The level of heart-type fatty acid binding protein in plasma was determined by enzyme immunoassay.
Results. According to the ROC analysis at patients with STEMI with a duration of clinical manifestations up to 3 hours, it was found that for heart-type fatty acid binding protein with a Cut-off point> 0.48 ng/ml, the sensitivity was 97.4% and the specificity was 97.3%. In the same subgroup, troponin I had a specificity of 74.7% and a sensitivity of 80.7% with a Cut-off point > 0.62 ng/ml.
Conclusions. The high diagnostic value of heart-type fatty acid binding protein for the early diagnosis of AMI has been established, and it exceeds the sensitivity of cardiac troponins at the first hours from the onset symptoms.
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