The role of functional activity of the thyroid gland and thyrotropic hormone on the development of eczema
DOI:
https://doi.org/10.32782/2077-6594/2024.1/11Keywords:
eczema, disease course, thyroxine, triiodothyronine, thyrotropic hormoneAbstract
Introduction. The pathogenesis of eczema is complex and multifactorial. However, a lot of research aimed to study it are often unstructured and chaotic in nature. It is believed that external, internal and autoimmune factors play an active role in the development of eczema. Among the internal factors, the functional state of the endocrine system is of great importance. However, the influence of hormonal levels on the clinical course of eczema remains unclear. Aim of the study. To assess the influence of the levels of thyroid and thyrotropic hormones on the clinical course of eczema. Materials and methods. 38 patients with eczema were observed. 14 of them were diagnosed with an infectious (microbial) form of dermatosis, 13 with true, and 11 with mycotic forms of dermatosis. Serum levels of thyroid and thyrotropic hormones were determined. Results and discussion. It has been proven that eczema patients have a probable increase in the content of thyroxine, triiodothyronine and stable levels of the thyrotropic hormone. These processes do not depend on the clinical form of dermatosis. The limited pathological process is characterized by the preservation of controlled fluctuations in thyroxine levels, compared to their growth in severe clinical manifestations. It was established that the elevation of triiodothyronine levels and stable thyrotropic hormone levels have no relation to the clinical form of eczema, the spread of the pathological process, the severity of the inflammatory process, and the duration of the disease. Conclusions. 1. In patients with true, infectious (microbial) and mycotic forms of eczema, there is a probable increase in the levels of thyroxine and triiodothyronine, while values of the thyrotropic hormone of the pituitary gland are stable. 2. The content of thyroxine depends on the prevalence of the pathological process and the severity of inflammatory process. 3. Increased levels of triiodothyronine and the stable levels of thyrotropic hormone of the pituitary gland are not associated with the clinical form of eczema, the spread of the rash, the severity of inflammatory process, and the duration of the course of eczema. 4. The obtained results should be taken into account when choosing an adequate therapeutic plan.
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