Physical activity as a key factor to restore pancreatic function in patients with type 2 diabetes (analytical review of scientific literature)
DOI:
https://doi.org/10.32782/2077-6594/2024.1/26Keywords:
type 2 diabetes, physical activity, pancreatic β-cell functionAbstract
Today, a physically active lifestyle is important for quality of life and plays an important role in the prevention and treatment of various chronic diseases, especially type 2 diabetes. The purpose of the study was to summarize current data on the effect of physical activity on the function of the pancreas in patients with type 2 diabetes. Materials and methods. A search was conducted for scientific articles, reviews and meta-analyses on the effect of physical activity on the function of the pancreas in type 2 diabetes. The selection criteria were determined taking into account the methodological quality of the studies, the number of participants and the observation period, in particular, studies that used objective measurement methods and took into account indicators for assessing physical activity and the state of the pancreas were included. Determination of the main parameters (glucose, insulin and other markers) characterizing the relationship between physical activity and pancreatic function, analysis of various methods of measuring physical activity, advantages or limitations of the results, analysis of their influence and statistical analysis of the pancreas, interpretation of data and results for generalization and formulation of conclusions regarding the influence of physical exercises on functioning. Study findings. The benefits of physical activity in type 2 diabetes include clinical changes such as improved organic response to insulin, reduction in glycosylated hemoglobin parameters, and weight control. There are two options for effective treatment and blood sugar control for people with type 2 diabetes: exercise and improved nutrition. Physical activity, including aerobic exercise, weight-bearing exercise, or a combination thereof, improves glucose regulation, lowers glycosylated hemoglobin, and restores pancreatic beta-cell function. Conclusion. Exercise should be one of the first treatment strategies recommended for patients with newly diagnosed type 2 diabetes.
References
Lautsch D, Wang T, Yang L, Rajpathak SN. Prevalence of Established Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus in the UK. Diabetes Ther. 2019 Dec; 10(6): 2131–7.
Heald AH, Stedman M, Davies M, Livingston M, Alshames R, Lunt M, Rayman G, Gadsby R. Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data. Cardiovasc Endocrinol Metab. 2020 Jun 2; 9(4): 183–185. DOI: 10.1097/XCE.0000000000000210. PMID: 33225235; PMCID: PMC7673790.
International Diabetes Federation. IDF diabetes atlas–8th edition. https://diabetesatlas.org/
Amanat S, Ghahri S, Dianatinasab A, Fararouei M, Dianatinasab M. Exercise and Type 2 Diabetes. In: Xiao J, editor. Physical Exercise for Human Health [Internet]. Singapore: Springer Singapore; 2020 [cited 2024 Jan 12]. p. 91–105. (Advances in Experimental Medicine and Biology; vol. 1228). http://link.springer.com/10.1007/978-981-15-1792-1_6
Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2019; 380(4): 347–57.
Birkeland KI, Bodegard J, Norhammar A, Kuiper JG, Georgiado E, BeekmanHendriks WL, et al. How representative of a general type 2 diabetes population are patients included in cardiovascular outcome trials with SGLT2 inhibitors? A large European observational study. Diabetes Obesity Metabolism. 2019 Apr; 21(4): 968–74.
American Diabetes Association Professional Practice Committee. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022; 45(Suppl 1):1.
Son, J, Accili, D. Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes. Experimental & Molecular Medicine. 2023; 1–7.
Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006; 29: 1433–1438.
Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013; 123: 2764–2772.
Madsen SM, Thorup AC, Overgaard K, Jeppesen PB. High intensity interval training improves glycaemic control and pancreatic beta cell function of type 2 diabetes patients. PloS One. 2015;10: e0133286.
Schwingshackl L, Missbach B, Dias S, König J, Hoffmann G. Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis. Diabetologia. 2014; 57: 1789–1797.
Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y. Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes. JCI Insight. 2021 Jan 11; 6(1): e143791. DOI: 10.1172/jci.insight.143791. PMID: 33427207; PMCID: PMC7821596.
Horoshko VI. MYOFASCIAL NECK PAIN SYNDROME IN WRESTLING ATHLETES: PREVENTION AND RECOVERY. Clin and prev med [Internet]. 2022 Aug 23 [cited 2024 Jan 12]; (3): 42–7. https://cp-medical.com/index.php/journal/article/view/216
Ramírez-Alvarado, Cintia. Aerobic exercise as a protective factor in older adults with type 2 diabetes mellitus. Mexican Journal of Medical Research ICSA. 2023; 11.22: 54–60.
Lawrence RD. The effect of exercise on insulin action in diabetes. Br Med J. 1926; 1: 648–650.
Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, et al. Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care. 2016 Nov 1; 39(11): 2065–79.
Lyngbaek MPP, Legaard GE, Bennetsen SL, et al. The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the «DOSE-EX» multi-arm parallelgroup randomised clinical trial. Trials. 2021 Apr 1; 22(1): 244. DOI: 10.1186/s13063-021-05207-7. PMID: 33794975; PMCID: PMC8017660.
Curran M, Drayson MT, Andrews RC, Zoppi C, Barlow JP, Solomon TPJ, et al. The benefits of physical exercise for the health of the pancreatic β-cell: a review of the evidence. Experimental Physiology. 2020 Apr; 105(4): 579–89.
Samuel, VT & Shulman, GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J. Clin. Invest. 2016; 126: 12–22.
Cusi K. The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes. Curr Diab Rep. 2010; 10: 306–315.
Jelleyman C, Yates T, O’Donovan G, et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev. 2015; 16: 942–961.
Jorge MLMP, de Oliveira VN, Resende NM, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011; 60: 1244–1252.
Kirwan JP, Solomon TPJ, Wojta DM, Staten MA, Holloszy JO. Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2009; 297: E151–E156.
Legaard GE, Lyngbæk MPP, Almdal TP, et al. Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial. Nat Metab. 2023 May; 5(5): 880–895. DOI: 10.1038/s42255-023-00799-7. Epub 2023 May 1. PMID: 37127822; PMCID: PMC10229430.
Lyngbaek MPP, Legaard GE, Bennetsen SL, et al. The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the «DOSE-EX» multi-arm parallelgroup randomised clinical trial. Trials. 2021 Apr 1; 22(1): 244. DOI: 10.1186/s13063-021-05207-7. PMID: 33794975; PMCID: PMC8017660.
Schwingshackl L, Missbach B, Dias S, König J, Hoffmann G. Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis. Diabetologia. 2014; 57: 1789–1797.