Sensitivity and specificity of the components of the metabolic syndrome in patients with arterial hypertension depending on the chronotype
DOI:
https://doi.org/10.32782/2077-6594/2023.2/16Keywords:
arterial hypertension, obesity, dyslipidemia, hyperglycemia, chronotype, ROC-analysisAbstract
Purpose – to find out the influence of the chronotype on the components of the metabolic syndrome in patients with arterial hypertension using the ROC analysis method. Materials and methods. The study included 42 patients diagnosed with stage 2 essential arterial hypertension who were undergoing inpatient treatment at the Torchyn District Hospital of the Torchyn Settlement Council. Results. The study showed that 52.38 % of patients with arterial hypertension have metabolic syndrome (MS), which probably does not depend on gender. Analyzing the components of MS, which were diagnosed in patients with hypertension, abdominal obesity was found in 61.90 % of patients, hypertriacylglycerolemia (TAG) in 42.86 %, and hyperglycemia in 26.19 % of people, which probably did not depend on gender. In patients with hypertension and evening chronotype, a waist circumference ≥ 98 cm is predicted (sensitivity 0.93; specificity 0.93), which corresponds to the abdominal type of obesity. SBP level ≥ 157.5 mmHg. and DBP ≥ 97.5 mmHg. associated with the evening chronotype. When analyzing the lipidogram indicators, it was found that in the case of evening chronotype in patients with hypertension, the predicted concentration of TAG ≥ 2.12 mmol/l (sensitivity – 0.86, specificity – 0.89) and HDL-C ≤ 0.97 mmol/l (sensitivity – 0.93, specificity – 0.90). In patients with hypertension with an evening chronotype, a glucose concentration ≥ 5.5 mmol/l is predicted (sensitivity – 0.64, specificity – 0.93). Conclusions. Patients with arterial hypertension with an evening chronotype are predicted to change the components of the metabolic syndrome, in particular, the progression of obesity, dyslipidemia, and hyperglycemia.
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