Personalized correction of the vaginal microbiome: innovative approaches based on 3P medicine principles
DOI:
https://doi.org/10.32782/2786-7684/2024-2-14Keywords:
vaginal microbiome, correction, personalized approach, pharmabiotics, lactobacilli, 3P medicineAbstract
Introduction. Healthy women of reproductive age are characterized by normomicrobiocenosis in the urogenital tract, which is in a state of dynamic balance and ensures the colonization resistance of the mucous membranes. Disruption of the vaginal microbiome balance may increase the risk of human papillomavirus (HPV) infection, which triggers the development of cervical cancer, infertility in women of reproductive age, and more. A new approach to solving the problem of correcting vaginal dysbiosis based on 3P medicine principles involves the use of individually selected pharmabiotics. The aim of the study was to investigate the features of vaginal microbiota in dysbiosis and to correct it using individually selected pharmabiotics with clinically proven effectiveness. Materials and Methods. The material for the study was vaginal secretions from women of reproductive age. Microbiological research was carried out through quantitative seeding of the biomaterial on nutrient media, followed by the identification of isolated microorganisms. Personalized selection of pharmabiotics was based on determining the antagonism between microorganisms isolated from the biomaterial and pharmabiotics. Results and Discussion. As a result of the bacteriological examination of vaginal secretions from women with various gynecological diseases, a shift in the vaginal secretion’s pH to the alkaline side was established (6.00 ± 0.12, whereas the normal reaction is acidic and has a pH of <4.5). Bacteriological analysis of vaginal secretions showed the presence of aerobic vaginitis and candidal vulvovaginitis, indicating microbial associations of type III and IV of the vagina, i.e., bacterial vaginosis. As a result of personalized selection, it was established that for the studied microbial associations of the vagina, the compositions of pharmabiotics differ significantly. Conclusions. Personalized correction of the vaginal microbiome based on the principles of 3P medicine is an effective method of individual prevention and treatment of vaginosis of established etiology.
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