Modifiable factors associated with breast cancer

Authors

DOI:

https://doi.org/10.32782/2077-6594/2023.3/03

Keywords:

modified risk factors, primary care, prevention, breast cancer.

Abstract

Purpose consists in determining the main modified risk factors among the population of Poltava region. Materials and methods. The research was conducted using a quantitative method according to case-control design. Women who underwent an oncological examination at the gynecologist of the Poltava Regional Clinical Hospital took part in the study. With the help of a specially developed questionnaire, a survey of 242 women was conducted (122 with established breast cancer and 120 healthy). Results. The analysis of the obtained data revealed that the influential factors are unsatisfactory financial situation (in 2.8 times), absence of children (in 1.7 times), history of abortions (in 2.06 times), use of contraceptives (in 2.8 times), smoking (3.1 times), heredity (5.6 times). There was also a reliable influence on the increase in the risk of breast cancer caused by some nutritional factors – excessive consumption of meat and insufficient consumption of fruits. Conclusions. As can be seen from the results of the conducted research, socio-demographic and behavioral factors increase the risk of developing breast cancer, and at the same time, the identification of important factors allows to orient primary care specialists of the region to their prevention.

References

Pittalis C, Panteli E, Schouten E, Magongwa I, Gajewski J. Breast and cervical cancer screening services in Malawi: a systematic review. BMC Cancer. 2020 Nov 12;20(1):1101. doi: 10.1186/s12885-020-07610-w

Han S, Guo Q, Wang T. Prognostic significance of interactions between ER alpha and ER beta and lymph node status in breast cancer cases. Asian Pac J Cancer Prev. 2013;14:6081–6084.

Рафальська ЯД., Косяченко КЛ. Сучасний стан епідеміології раку молочної залози в Україні та місті Києві. У: Актуальні питання сучасної медицини і фармації–2023; 25–26 трав. 2023; Запоріжжя. Запоріжжя: ЗДМФУ; 2023. с. 174.

Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, Friedman ER, Slingerland JM. Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA Cancer J Clin. 2017 Sep;67(5):378-397. doi: 10.3322/caac.21405

Tamimi R. Population attributable risk of modifiable and nonmodifiable breast cancer risk factors in postmenopausal breast cancer. Am J Epidemiol. 2016; 184: 884–893. doi: 10.1093/aje/kww145

Cohen SY, Stoll CR, Anandarajah A, Doering M, Colditz GA. Modifiable risk factors in women at high risk of breast cancer: a systematic review. Breast Cancer Res. 2023 Apr 24;25(1):45. doi: 10.1186/s13058-023-01636-1

Barnett GC, Shah M, Redman K, Easton DF, Ponder BAJ, Pharoah PDP. Risk Factors for the Incidence of Breast Cancer: Do They Affect Survival From the Disease? J Clin Oncol 2008;26(20):3310–6 doi: 10.1200/jco.2006.10.3168

Reeves GK, Patterson J, Vessey MP, Yeates D, Jones L. Hormonal and other factors in relation to survival among breast cancer patients.Int J Cancer 2000; 89(3): 293–9 doi: 10.1002/1097-0215(20000520)89:3<293::Aid-ijc13>3.0.Co;2-r

Lu Y, Ma H, Malone KE, Norman SA, Sullivan-Halley J, Strom BL, et al. Oral Contraceptive Use and Survival in Women with Invasive Breast Cancer. Cancer Epidemiol Biomarkers Prev 2011; 20(7): 1391–7 doi: 10.1158/1055-9965.EPI-11-0022

Trivers KF, Gammon MD, Abrahamson PE, Lund MJ, Flagg EW, Moorman PG, et al. Oral Contraceptives and Survival in Breast Cancer Patients Aged 20 to 54 Years. Cancer Epidemiol Biomarkers Prev 2007; 16(9): 1822–7 doi: 10.1158/1055-9965.EPI-07-0053

Yu X, Zhou S, Wang J, Zhang Q, Hou J, Zhu L, et al. Hormone replacement therapy and breast cancer survival: a systematic review and meta-analysis of observational studies. Breast Cancer 2017;24(5):643–57 doi: 10.1007/s12282-017-0789-5

Meurer L, Lená S. Cancer recurrence and mortality in women using hormone replacement therapy: meta-analysis. J Fam Pract 2002; 51(12): 1056–62.

Chlebowski RT, Manson JE, Anderson GL, Cauley JA, Aragaki AK, Stefanick ML, et al. Estrogen plus progestin and breast cancer incidence and mortality in the Women’s Health Initiative Observational Study. J Natl Cancer Inst 2013;105(8):526–35 doi: 10.1093/jnci/djt043

Beral V, Peto R, Pirie K, Reeves G. Menopausal hormone therapy and 20-year breast cancer mortality. Lancet 2019; 394 (10204): 1139 doi: 10.1016/S0140-6736(19)32033-1

Xiao Y, Xia J, Li L, Ke Y, Cheng J, Xie Y, Chu W, Cheung P, Kim JH, Colditz GA, Tamimi RM, Su X. Associations between dietary patterns and the risk of breast cancer: a systematic review and meta-analysis of observational studies. Breast Cancer Res. 2019 Jan 29;21(1):16. doi: 10.1186/s13058-019-1096-1

Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008;67(3):253–256. doi: 10.1017/ S002966510800712X

Brennan SF, Cantwell MM, Cardwell CR, Velentzis LS, Woodside JV. Dietary patterns and breast cancer risk: a systematic review and meta-analysis. Am J Clin Nutr. 2010; 91(5): 1294–1302. doi: 10.3945/ajcn.2009.28796

Rose P, Huang Q, Ong CN, Whiteman M. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol. 2005; 209(2):105–113. doi: 10.1016/j. taap.2005.04.010

Johnson IT. Phytochemicals and cancer. Proc Nutr Soc.2007;66(2):207–215. doi: 10.1017/S0029665107005459

Martin LJ, Li Q, Melnichouk O, Greenberg C, Minkin S, Hislop G, Boyd NF. A randomized trial of dietary intervention for breast cancer prevention. Cancer Res. 2011;71(1):123–133. doi: 10.1158/0008-5472.CAN-10-1436

Passarelli MN, Newcomb PA, Hampton JM, Trentham-Dietz A, Titus LJ, Egan KM, et al. Cigarette Smoking Before and After Breast Cancer Diagnosis: Mortality From Breast Cancer and Smoking-Related Diseases. J Clin Oncol 2016;34(12):1315–22. doi: 10.1200/jco.2015.63.9328

Morra A, Jung AY, Behrens S, Keeman R, Ahearn TU, Anton-Culver H, et al. ABCTB Investigators; NBCS Collaborators. Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2021 Apr;30(4):623-642. doi: 10.1158/1055-9965.EPI-20-0924

Published

2023-11-13