Features of the structure of lymphoid tissue of serous membranes of rats in normal and with adhesion disease

Abstract

Introduction. From the number of abdominal disorders due to military actions due to postoperative complications, about 20% of patients suffer from a progressive adhesion process. And 30% of patients are forced to resort to repeated surgical procedures due to adhesive intestinal obstruction. The pathogenesis of adhesion disease has not yet been fully elucidated. It is still necessary to study the mechanism of formation of adhesions in the abdominal cavity with adhesion obstruction in order to develop tactics and a comprehensive approach to their treatment. SALC and FALC have been described as important centers for providing the first line of defense in the structure of mucous membranes due to innate and acquired immunity. The physiological significance of the close connection of lymphoid clusters with the visceral and parietal peritoneum requires further study. Purpose: to investigate the peculiarities of the topography and number of lymphoid clusters associated with adipose tissue of FALC and associated with the serous membrane of SALC in normal and in adhesion disease in rats. Research methodology and methods: preparation, macroscopic, microscopic, histological (production of film preparations), staining with hematoxylin and eosin, mathematical. Summary of the main material of the study: The results showed that there are significant features and differences in the structure of adhesions depending on the term and stage of the disease. The area of sero-associated SALC and FALC varied at each term of adhesion disease development. In experimental animals on the 14th and 21st days, it was found that the lymphoid clusters had mostly an irregular elongated shape and were localized mainly near blood vessels. The general topographical pattern of milk spots in the experimental groups was similar to that in animals of the intact group, but during the experiment, an increase in their diameter and number of clusters was observed. Conclusions from the study. Studies have shown that adhesion disease is characterized by an increase in the size of SALC and FALC lymphoid clusters and their number per studied unit of intestinal mesentery area from the 7th to the 21st day of the experimental simulation: on the 7th day, single small granulations with a size of 0.6-0.8 mm were observed; on the 14th day, 4.5 SALC and 3.1 FALC were found on the studied area, white granular clusters of 0.5-1.3 mm in size; on the 21st day – abundant accumulation of oval whitish structures with a diameter of 1.2-1.8 mm in the number of 7.2 and 9.1 per studied area, respectively.