Analysis of post-COVID syndrome and preventive strategies in diabetes mellitus

Authors

DOI:

https://doi.org/10.32782/2077-6594/2025.3/03

Keywords:

long COVID, metabolic comorbidity, micronutrient supplementation, immune system support, chronic disease management, nutritional interventions

Abstract

Purpose. The aim of this paper is to analyze the factors contributing to the occurrence of post-COVID syndrome in patients with diabetes mellitus and to highlight the importance of preventive strategies, including nutritional support, in managing the long-term consequences following COVID-19.Material and methods. The study included 181 patients with diabetes mellitus who had recovered from COVID-19 and were hospitalized in Slovakia. Data were collected using an anonymous questionnaire. Statistical analysis was performed using SPSS software, employing the chi-square test and the non-parametric Mann–Whitney and Kruskal–Wallis tests.Results. The results showed that the occurrence of post-COVID syndrome was associated with the duration of diabetes – patients with a longer disease duration more frequently reported post-COVID symptoms. The most common symptoms were fatigue, joint and muscle pain, shortness of breath, and sleep disturbances. A significant difference was also found in the use of vitamins and minerals – patients without symptoms more often reported regular supplementation (e.g., vitamins C, D, zinc, B-complex), suggesting a potential protective effect. Neither gender nor age showed a statistically significant impact on the occurrence of symptoms. Although slight differences were observed between age groups, the p-value confirmed they were not significant. This result may be related to the uneven distribution of respondents across age categories and the variability of symptoms.Conclusions. Post-COVID syndrome in diabetic patients represents a clinically serious issue that requires an individualized and multidisciplinary approach, including targeted prevention and nutritional support.

References

Vansač P, Kenderešová, E. Etické problémy človeka s civilizačným ochorením, In: BABEČKA J., BERETA M., ZASTKO, L., (Eds.) Ružomberské zdravotnícke dni 2024 – XVIII. ročník Zborník z medzinárodnej vedecko-odbornej konferencie, VERBUM – vydavateľstvo KU, Ružomberok 2024: 22–229, ISBN 978-80-561-1125-3 (in Slovak)

Mokan M, Martinka E, Galajda P, et al. Diabetes mellitus a vybrane metabolicke ochorenia. Turany: Vydavatelstvo P + M; 2008. ISBN: 978-80-969713-9-8 (in Slovak)

Li B, Yang S, Hou N. Could vitamin D supplementation play a role against COVID-19? Front Immunol. 2022;13:967215. doi.org/10.3389/fimmu.2022.967215.

Bae M, Kim H. Mini-review on the roles of vitamin C, vitamin D, and selenium in the immune system against COVID-19. Molecules. 2020 Nov 16;25(22):5346. doi: 10.3390/molecules25225346.

Holford P, Carr AC, Jovic TH, Ali SR, Whitaker IS, Marik PE, Smith AD. Vitamin C – An adjunctive therapy for respiratory infection, sepsis and COVID-19. Nutrients. 2020;12(12):3760. doi: 10.3390/nu12123760.

Peterson CT, Rodionov DA, Osterman AL, Peterson SN. B vitamins and their role in immune regulation and cancer. Nutrients. 2020 Nov 4;12(11):3380. doi: 10.3390/nu12113380.

Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of Vitamin A in the Immune System. J Clin Med. 2018 Sep 6;7(9):258. doi: 10.3390/jcm7090258.

Heesakkers H, van der Hoeven JG, Corsten S, et al. Clinical outcomes among patients with 1-year survival following intensive care unit treatment for COVID-19. JAMA. 2022;327(6):559–565. doi: 10.1001/jama.2022.0040.

Vansač, P. Spiritualita ako opora onkologických pacientov, In: BABEČKA, J. LACKO, A., BERETA, M., ANDRÁSI, I. (Eds.).: Ružomberské zdravotnícke dni 2021 – XV. ročník, Zborník z medzinárodnej konferencie, VERBUM – vydavateľstvo KU, Ružomberok 2021, s. 170–178, ISBN 978-80-561-0903-8 (in Slovak).

Ivanková V, Belovičová M. Dopad pandémie na zdravotný systém, Sociálno-zdravotnícke spektrum, 2021, ISSN: 1339-2379 (online) (August, 2021) (v slovenčine) (in Slovak).

Vansač, P., Noga, V. Spiritual accompaniment of patients in palliative cere affected by the Covid – 19 pandemic, Acta Missiologica, vol. 15, no. 2, 2021, p. 213–233, ISSN: 2453-7160 (online) (October, 2021).

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. doi: 10.1136/ bmj.i6583.

Xu W, Wang P, Wan J, Tan Y, Liu Y, Chen Q, Zheng Y, Yu X, Fan S, Dominguez JL, Zhang Y. Effect of vitamin C supple-mentation on outcomes in patients with COVID-19: a systematic review and meta-analysis. Front Nutr. 2024 Oct 3;11:1465670. doi: 10.3389/fnut.2024.1465670.

Mittal J, Ghosh A, Bhatt SP, Anoop S, Ansari IA, Misra A. High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: a case-control study. Diabetes Metab Syndr. 2021;15:102302. doi: 10.1016/j.dsx.2021.102302.

Jayasinghe S, Misra A, Hills AP. Post COVID 19 syndrome and type 2 diabetes: Primacy of exercise in prevention and man- agement. Diabetes Metab Syndr. 2022 Jan;16(1):102379. Epub 2021 Dec 29. doi: 10.1016/j.dsx.2021.102379.

Sosale A, Sosale B, Kesavadev J, Chawla M, Reddy S, Saboo B, Misra A. Steroid use during COVID-19 infection and hyperglycemia – What a physician should know. Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102167. doi: 10.1016/j.dsx.2021.06.004.

Jayasinghe S, Misra A, Hills AP. Post COVID 19 syndrome and type 2 diabetes: Primacy of exercise in prevention and man- agement. Diabetes Metab Syndr. 2022 Jan;16(1):102379. Epub 2021 Dec 29. doi: 10.1016/j.dsx.2021.102379.

Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infec- tions: a systematic review. Clin Neurol Neurosurg. 2020;194:105921. doi: 10.1016/j.clineuro.2020.105921.

Liu Y, Zhang T, Wang L, Zhao Y, Chen W, Fang X, et al. Cognitive impairment in type 2 diabetes mellitus patients with long COVID: a prospective observational study. J Clin Endocrinol Metab. 2024;109(2):e305–e313. doi: 10.1210/clinem/dgad589.

Raveendran AV, Misra A. Post COVID-19 Syndrome (“Long COVID”) and diabetes: challenges in diagnosis and manage- ment. Diabetes Metab Syndr. 2021;15:102235. doi: 10.1016/j.dsx.2021.102235.

Suwanwongse K, Shabarek N. Newly diagnosed diabetes mellitus, DKA, and COVID 19: Causality or coincidence? A report of three cases. J Med Virol. 2021;93(2):1150–1153. doi: 10.1002/jmv.26339.

Barkasi, D. Dopad pandémie COVID-19 na životný štýl. In: BELOVIČOVÁ, M., MAKARA, P., POPOVIČOVÁ, M. (Eds.), Dni praktickej obezitológie a metabolického syndrómu 2022, Zborník vedeckých prác, Collegium Humanum Warsaw Management University – vydavateľstvo, Warszawa 2022. s. 48 – 69, ISBN 978-83-958245-5-5 (in Slovak).

Juriš P, Diabelková J, Bárta R, Sabo S. Analýza rizika šírenia sa vírusu SARS-CoV-2 v prostredí zariadení sociálnych služieb a zdravotníckej starostlivosti. In: Juriš P, editor. Zdravotné a sociálne problémy seniorov v súčasnosti: Zborník vedecko-výskumných prác s príležitosti Medzinárodného dňa seniorov (1. október 2022). Báčsky Petrovec (Srbsko): Pharm advice plus; 2022. p. 182–186. ISBN: 978-86-82536-00-0 (in Slovak).

Downloads

Published

2025-09-25

How to Cite

Поповічова M., Беловiчова M., & Миронюк, І. (2025). Analysis of post-COVID syndrome and preventive strategies in diabetes mellitus. Ukraine. Nation’s Health, (3), 22–30. https://doi.org/10.32782/2077-6594/2025.3/03

Issue

Section

Public health