DISTURBANCES IN THE MUCOUS MEMBRANE OF THE ORAL CAVITY OF RATS AFTER CONSUMPTION OF EXCESS SUGAR AND ALUMINUM CHLORIDE
DOI:
https://doi.org/10.32782/1998-6475.2025.58.20Keywords:
pathogenic factors, markers of inflammation, microbial insemination, antioxidant protectionAbstract
The work studied inflammation markers (elastase and acid phosphatase activity), as well as an indicator of microbial contamination (urease activity) in the mucous membrane of the oral cavity of rats after consuming excess sugar and aluminum chloride. The influence of pathogenic factors on the activity of antioxidant protection and the degree of lipid peroxidation in the mucous membrane of the oral cavity of rats was studied. The results of the study indicate the development of inflammatory processes and the reproduction of opportunistic microbiota in the oral cavity of experimental groups of animals, which were more pronounced with the combined consumption of a large amount of sugar with an excess of aluminum. Suppression of antioxidant protection and, as a result, an outbreak of lipid peroxidation were observed.
References
HAGHDOOST, A., BAKHSHANDEH, S., TOHIDI, S., GHORBANI, Z., NAMDARI, M. (2023) Improvement of oral health knowledge and behavior of diabetic patients: an interventional study using the social media. BMC Oral Health, 23(1), 359–362.
HLUKH, O. S., SYMKANYCH, O. I., BESKID, A. M., MOLNAR, D. I. (2016) Bezpeka vykorystannya alyuminiyevoho posudu pid chas pryhotuvannya kharchovykh produktiv [Safety of using aluminum utensils during food preparation]. Naukovyi visnyk Uzhhorodskoho universytetu. Seriia: Khimiia, 35(1), 84–86. (in Ukrainian).
HUSSEINH, H., MAHMOUD, M. (2013) Effects of maternal administration of aluminum chloride on the development of the skeletal system of albino rat fetuses- protective role of saffon. European Journal of Anatomy, 17(2), 63–71.
KHODAKOV, I. V., KHROMAGINA, L. M., MA KA- REN KO, O. A., MUDRYK, L. M. (2023) Modyfikatsiya kazeyino-sakharoznoyi diyety M. S. Buhayovoyi ta S. A. Nikitina (1954) dlya modelyuvannya kariyesu zubiv u shchuriv [Modification of casein-sucrose diet M. S. Bugaiova and S. A. Nikitin (1954) for modeling dental caries in rats]. Visnyk stomatolohii, 1 (122), 47, 71–76. (in Ukrainian).
KHODAKOV, I. V., MAKARENKO, O. A., KO LOM IY- CHUK, T. V., SOKOLOV, D. V., BATURIN, D. S. (2022) Doslidzhennya mozhlyvosti profilaktyky Minerolom toksychnoho efektu yoniv alyuminiyu na kistkovu tkanynu shchuriv [Research on the possibility of prevention of the toxic effect of aluminum ions on the bone tissue of rats by Mineralom]. Visnyk ONU, Biolohiya, 2(51), 88–101. (in Ukrainian).
LUKIW, W. J., KRUCK, T. R., PERCY, M. E., POGUE, A. I., ALEXANDROV, P. N., WALSH, W. J., SHARFMAN, N. M., JABER, V. R., ZHAO, Y., LI, W., BERGERON, C., CULICCHIA, F., FANG, Z., MCLACHLAN, D. R. C. (2019) Aluminum in neurological disease – a 36 year multicenter study. Journal Alzheimer’s Disease. Parkinsonism, 8(6), 457–459.
MAKARENKO, O. A., KHROMAGINA, L. M., KHO- DAK OV, I. V., MAIKOVA, H. V., MUDRYK, L. M., KIKA, V. V., MOHILEVSKA, T. V. (2022) Metody doslidzhennia stanu kyshechnyku ta kistok u laboratornykh shchuriv. Dovidnyk [Methods of researching the state of intestines and bones in laboratory rats. Handbook]. Publisher S. L. Nazarchuk, Odesa. (in Ukrainian).
RAHIMZADEH, M. R., RAHIMZADEH, M. R., KAZEMI, S., AMIRI, R. J., PIRZADEH, M., MOGHADAMNIA, A. A. (2022) Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication. Emergency Medicine International, 11, 480–553.
SON, Y. B., KANG, Y. H., LEE, H. J., JANG, S. J., BHARTI, D., LEE, S. L., JEON, B. G., PARK, B. W., RHO, G.J. (2021) Evaluation of odonto/osteogenic differentiation potential from different regions derived dental tissue stem cells and effect of 17β-estradiol on efficiency. BMC Oral Health, 21(1), 15–18.





