Justification of the use of metabolomics methods in dentistry
DOI:
https://doi.org/10.32782/2786-7684/2025-2-12Keywords:
dentistry, oral microbiome, acid resistance, cariogenic risk, dental caries, metabolomics (OMICS)Abstract
Introduction. Omics technologies (omics) are a complex of modern technologies in molecular biology and bioinformatics. Metabolomics is a science that specializes in the comprehensive study of metabolic reactions for the systematic characterization of metabolites in the human body. Next-generation Omix implements an approach to clinical workflows, thus providing insights for the development and repurposing of pharmaceutical products.The aim of the study. To conduct an analysis of literary sources regarding the use of metabolomics methods for the diagnosis of the normal state and incidence of major dental diseases.The results. A search was conducted for scientific studies contained in PubMed, Scopus, Web of Science and Google Scholar databases and related to the identification of salivary metabolites and proteins associated with the risk of development and progression of major dental diseases. Metabolomics provides opportunities not only to determine the human metabolome, but also determines information about the interaction of metabolites and the effect of pharmacological drugs on the level of metabolites (pharmacometabolomics), which can be used in nutrition, biochemistry, clinical chemistry, clinical genetics and medicine.Conclusion. The achievements of recent years, which are devoted to the results of the use of metabolomics methods for the diagnosis of the normal state and incidence of major dental diseases, are quite common. Expanding the range of their application will allow unifying algorithms for preclinical diagnosis of such common diseases as caries and periodontal tissue diseases among the population.
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