Efficiency of using oral elixir from amaranth seeds in complex treatment of patients with generalized periodontitis

Authors

DOI:

https://doi.org/10.32782/2786-7684/2025-2-18

Keywords:

generalized periodontitis, amaranth, oral elixir, oral hygiene, treatment

Abstract

Introduction. Relevant is the further search for medicines for the prevention and treatment of periodontitis. It is considered justified the use of drugs of plant origin, which are devoid of side effects and exhibit a variety of biological functions. Of interest is the study of the therapeutic effects of oral elixir from amaranth seeds, which contains a natural complex of biologically active substances: squalene, amino acids (lysine, tryptophan), bioflavonoids (hesperidin), vitamins В1, В2, РР, С, Р, Е, А, macro- and microelements, prebiotic inulin and calcium citrate.The aim of the study is to determine the efficiency of the use of oral elixir from amaranth seeds in the complex treatment of patients with generalized periodontitis.Materials and methods. Examination and treatment of 88 patients with generalized periodontitis of the initial-I, I degree, aged 18–35 years, was conducted. All patients were divided into two groups: the main group and the comparison group. Patients of the main group after conventional therapy of periodontitis were prescribed an elixir "Mint + amaranth extract" for constant daily use as a rinse 2 times a day, after toothbrushing. The efficiency of the oral elixir was evaluated based on clinical and radiological parameters in the nearest (after 1 month) and distant (after 6 and 12 months) observation periods.The results. It was found that in patients with periodontitis of the main group, the dynamics of decline in all indicators (hygienic index, PMA, bleeding index, Russell PI) was most pronounced than in the comparison group, at all observation periods – after 1, 6 and 12 months. In a comparative analysis of long-term treatment results, it was proved that the constant use of a oral elixir contributed to the stable clinical and radiological stabilization of the dystrophic-inflammatory process in the periodontium.Conclusion. Long-term daily use of oral elixir from amaranth seeds after conventional treatment of patients with generalized periodontitis of the initial-I, I degree leads to improvement of oral hygiene and long-term clinical and radiological stabilization in periodontal tissues.

References

Frencken JE, Sharma P, Stenhouse L, Green D, Laverty D, Dietrich T. Global epidemiology of dental caries and severe periodontitis – a comprehensive review. J Clin Periodontol. 2017;44(Suppl.18):S94-S105. doi: 10.1111/jcpe.12677.

Danylevskyi MF, Borysenko AV, Politun AM, Sidelnykova LF, Nesyn OF. Terapevtychna stomatolohiia. Zakhvoriuvannia parodonta. Kyiv: Medytsyna;2018. T3. 624 s.

Chumakova YuH. Patohenetychne obgruntuvannia metodiv kompleksnoho likuvannia heneralizovanoho parodontytu. Avtoref. dys. dokt. med.nauk: Odesa, 2008. 39 s. Dostupno: https://dspace.onua.edu.ua/server/api/core/bitstreams/333111f2-5b05-4326-8ef2-fa0fd5778e0b/content

Makarenko O, Levitsky А. Biochemical mechanisms of therapeutic and prophylactic effects of bioflavonoids. J Pharmacy Pharmacol. 2016;(4):451-6. doi: 10.17265/2328-2150/2016.08.013

Silva-Sánchez C, De La Rosa AB, León-Galván MF, de Lumen BO, de León-Rodríguez A, De Mejía EG. Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed. J Agric Food Chem. 2008;56(4):1233-40. https://doi.org/10.1021/jf072911z

Sabbione AC, Scilingo A, Añón MC. Potential antithrombotic activity detected in amaranth proteins and its hydrolysates. LWT-Food Science and Technology. 2015;60(1):171-7. http://dx.doi.org/10.1016/j.lwt.2014.07.015

Lamothe LM, Srichuwong S, Reuhs BL, Hamaker BR. Quinoa (Chenopodium quinoa W.) and amaranth (Amaranthus caudatus L.) provide dietary fibres high in pectic substances and xyloglucans. Food chemistry. 2015;167:490-6. https://doi.org/10.1016/j.foodchem.2014.07.022

He HP., Corke H. Oil and squalene in amaranthus grain and leaf. J Agric Food Chem. 2003;51(27):7913-20. https://doi.org/10.1021/jf030489q

Ibrahim NI, Naina Mohamed I. Interdependence of anti-inflammatory and antioxidant properties of squalene-implication for cardiovascular health. Life. 2012;11(2):103. https://doi.org/10.3390/life11020103

Güneş FE. Medical use of squalene as a natural antioxidant. Journal of Marmara University Institute of Health Sciences. 2013;3(4). DOI: 10.5455/musbed.20131213100404

ŞAKUL AA., Ozansoy M, Elibol B, Ayla Ş, GÜNAL MY, Yozgat Y, et al. Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice. Turk J Biol. 2019;43(3):179-88. https://doi.org/10.3906/biy-1902-77

Reddy LH, Couvreur P. Squalene: A natural triterpene for use in disease management and therapy. Advanced Drug Delivery Reviews. 2009;61(15): 1412-26. https://doi.org/10.1016/j.addr.2009.09.005

Quiroga AV, Barrio DA, Añón MC. Amaranth lectin presents potential antitumor properties. LWT-Food Sci Technol. 2015;60(1):478-85. http://dx.doi.org/10.1016/j.lwt.2014.07.035

Selivanska IО, Shumyvoda YA. Comprehensive biochemical determination of the therapeutic and preventive effectiveness of herbal remedies for periodontal damage in rats that consumed fried sunflower oil. J Educ Health Sport. 2025;79:59319. https://dx.doi.org/10.12775/JEHS.2025.79.59319

Shrivastava D, Natoli V, Srivastava KC, Alzoubi IA, Nagy AI, Hamza MO, et al. Novel approach to dental biofilm management through Guided Biofilm Therapy (GBT): A Review. Microorganisms. 2021;9(9):1966-82. https://doi.org/10.3390/microorganisms9091966

Published

2025-06-30

Issue

Section

DENTISTRY