Features of adaptive mechanisms of the cardiovascular system in acquired myopia
DOI:
https://doi.org/10.32782/2786-7684/2025-2-23Keywords:
myopia, cardiovascular system, hemodynamics, adaptive potentialAbstract
Introduction. Acquired myopia is one of the most common refractive anomalies in modern society, and the number of cases continues to grow globally each year. Various factors such as prolonged visual strain, insufficient physical activity, improper lighting, and genetic predisposition contribute to its development and progression. In this context, the study of systemic changes in the body, particularly the adaptive mechanisms of the cardiovascular system in the presence of myopia, is highly relevant.Aim of the work. Conducting a comprehensive analysis of hemodynamic indicators that reflect functional changes in the cardiovascular system, including the adaptive potential, in individuals with acquired myopia.Materials and methods of the study. The study was conducted among 146 volunteers aged 18-35, divided into a control group and a group of individuals with acquired myopia of varying degrees. A clinical and functional examination of the cardiovascular system was performed, key hemodynamic parameters were determined, and calculations and comparisons of functional status indicators between the two groups were carried out.Research results and their discussion. In individuals with acquired myopia, a significant increase was found in systolic blood pressure, the circulatory efficiency coefficient, Robinson index, and adaptive potential. An increase was also observed in heart rate, diastolic and pulse blood pressure, stroke volume, cardiac output, left ventricular work power, systolic index, functional state coefficients of the circulatory and cardiorespiratory systems, Kerdo vegetative index, as well as cardiac and stroke indices. A decrease was noted in heart volume, Hildenbrandt coefficient, total peripheral resistance, and specific peripheral resistance.Conclusions. Acquired myopia is accompanied by systemic functional changes in the cardiovascular system, which are compensatory in nature and may reflect the body's adaptive response to the load on the visual analyzer.
References
Foster PJ, Jiang Y. Epidemiology of myopia. Eye (Lond). 2014;28(2):202-8. https://doi.org/10.1038/eye.2013.280
Baird PN, Saw SM, Lanca C, et al. Myopia. Nat Rev Dis Primers. 2020;6:99. https://doi.org/10.1038/s41572-020-00231-4
French AN, Morgan IG, Mitchell P, Rose KA. Risk Factors for Incident Myopia in Australian Schoolchildren: the Sydney Adolescent Vascular and Eye Study. Ophthalmology. 2013;120(10):2100-8. https://doi.org/10.1016/j.ophtha.2013.02.035
McMonnies CW. An examination of the relation between intraocular pressure, fundal stretching and myopic pathology. Clin Exp Optom. 2016;99(2):113-9. https://doi.org/10.1111/cxo.12302
Chakraborty R, Read SA, Vincent SJ. Understanding Myopia: Pathogenesis and Mechanisms. Updates on Myopia. 2019:65-94. https://doi.org/10.1007/978-981-13-8491-2_4
Zhou X, Pardue MT, Iuvone PM, Qu J. Dopamine signaling and myopia development: What are the key challenges. Prog Retin Eye Res. 2017;61:60-71. https://doi.org/10.1016/j.preteyeres.2017.06.003
Yu M, Liu W, Wang B, Dai J. Short Wavelength (Blue) Light Is Protective for Lens-Induced Myopia in Guinea Pigs Potentially Through a Retinoic Acid–Related Mechanism. Invest Ophthalmol Vis Sci. 2021;62(1):21. https://doi.org/10.1167/iovs.62.1.21
Liu Z, Xiu Y, Qiu F, et al. Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated. Invest Ophthalmol Vis Sci. 2021;62(9):21. https://doi.org/10.1167/iovs.62.9.21
Zhu X, Du Y, Li D, et al. Aberrant TGF-beta1 signaling by MAF underlies lens growth in high myopia. Nat Commun. 2021;12(1):2102. https://doi.org/10.1038/s41467-021-22041-2
Zhao F, Zhang D, Zhou Q, et al. Scleral HIF-1alpha and myopia pathogenesis. EBioMedicine. 2020;57:102878. https://doi.org/10.1016/j.ebiom.2020.102878
Tsybulska TIe., Horbachova SV., Zavhorodnia TS. Kliniko-diahnostychne znachennia porushen elektrolitnoho obminu u ditei z nabutoiu miopiieiu [Clinical diagnostic significance of electrolyte imbalance in children with acquired myopia]. Oftalmolohichnyi zhurnal. 2019;3:14-19. [in Ukrainian].
Ivasenko AIu. Pokaznyky lipidnoho obminu u osib z korotkozoristiu [Indicators of lipid metabolism in individuals with acquired myopia]. Acta Carpathica. 2023;2(40):44-50. Available from: https://doi.org/10.32782/2450-8640.2023.2.5 [in Ukrainian].
Perekhodko KM. Vplyv nabutoi korotkozorosti slabkoho stupenia na deiaki biokhimichni pokaznyky krovi [The impact of mild acquired myopia on certain biochemical blood parameters]. In: Mezhiievska I, Maslovskyi V, Pavlov S, editors. Medicine and psychology: modern problems, new technologies and ways of developing outdated theories: collective monograph. Boston: Primedia eLaunch; 2024;185-92. Available from: https://doi.org/10.46299/ISG.2024.MONO.MED.1.10.2 [in Ukrainian].
Kolesnyk YuI, Sheiko VI. Сhanges of indexes of humoral immunity in the conditions of acquired myopia of different degree. Bulletin of problems biology and medicine. 2018;4(2):383-386. https://doi.org/10.29254/2077-4214-2018-4-2-147-383-386
Kolesnyk Yu, Sheiko V, Dereka T. Comparison of Indicators of cellular and humoral immunity in acquired myopia and high degree. Zdravotnicke listy. 2020;8(4):36-42. https://doi.org/10.32782/1339-3022/2020/4.8.8
Li Q, Yang J, He Y, Wang T, Zhong L, Zhu Z, Wang T, Ling S. Investigation of the psychological health of first-year high school students with myopia in Guangzhou. Brain Behav. 2020; Apr;10(4):e01594. https://doi.org/10.1002/brb3.1594
Korkoman AJ, Korkoman SJ, Alotaibi MM, Bukhari RA, Alsalmi RA, Alsaleem H, Alahmed S, Alrehaili A, Almishali FF, Al-Amri A. Association between myopia and psychological well-being: a cross-sectional study based on Saudi university students. International Journal of Research in Medical Sciences. 2025 Apr;13(4):1438-1446. https://doi.org/10.18203/2320-6012.ijrms20250964
Ivasenko AIu., Sheiko VI. Pokaznyky tsentralnoi hemodynamiky na tli nabutoi korotkozorosti [Central hemodynamic parameters in the context of Acquired Myopia]. Aktualni problemy suchasnoi medytsyny: Visnyk Ukrainskoi medychnoi stomatolohichnoi akademii. 2024;24(2):27-30. Available from: https://doi.org/10.31718/2077-1096.24.2.27 [in Ukrainian].
Ivasenko AIu. Osoblyvosti pokaznykiv elektrokardiohramy v osib z nabutoiu korotkozoristiu [Features of electrocardiogram parameters in individuals with acquired myopia]. In: Mezhiievska I, Maslovskyi V, Pavlov S, editors. Medicine and psychology: modern problems, new technologies and ways of developing outdated theories: collective monograph. Boston: Primedia eLaunch; 2024. p. 176-84. Available from: https://doi.org/10.46299/ISG.2024.MONO.MED.1.10.1 [in Ukrainian]
Kim HG, Cheon EJ, Bai DS, Lee YH, Koo BH. Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature. Psychiatry Investig. 2018 Mar;15(3):235-245. https://doi.org/10.30773/pi.2017.08.17
William YJ. Neurological Implications in the Treatment of Myopia by Means of Orthoculogy. J Neurol Neurophysiol. 2014;5(6):1000257. https://doi.org/10.4172/2155-9562.1000257
McMonnies CW. An examination of the relation between intraocular pressure, fundal stretching and myopic pathology. Clin Exp Optom. 2016 Mar;99(2):113-9. https://doi.org/10.1111/cxo.12302
Wielkiewicz RM. Myopia is an Adaptive Characteristic of Vision: Not a Disease or Defect. Review of General Psychology. 2016;20(4):437-451. https://doi.org/10.1037/gpr0000090
Xia T, Nakayama K. Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis. J Physiol Anthropol. 2023 Nov 2;42(1):25. https://doi.org/10.1186/s40101-023-00341-4
Poruchynska TF, Pasychniuk IF, Poruchynskyi AI. Ekolohichna fiziolohiia liudyny [Human ecological physiology]. Lutsk, 2021;272 p. [in Ukrainian].
Moiseienko RO, Holubchykov MV, Mykhalchuk VM, ta in. Oftalmolohichna dopomoha v Ukraini za 2014-2017 roky (analitychnostatystychnyi dovidnyk) [Оphthalmological care in Ukraine in 2014-2017 (Analytical and statistical reference book)]. Kyiv, 2018; 314 p. [in Ukrainian].
World Report on Vision. World Health Organization 2019. 180 p. Available from: https://www.who.int/publications/i/item/world-report-on-vision
Shevchuk VH. Fiziolohiia [Physiology]. Vinnytsia : Nova knyha, 2018;447 p. [in Ukrainian].
Maltseva OB, Liakhovets LO. Funktsionalna ta kliniko-laboratorna diahnostyka [Functional and clinical-laboratory diagnostics]. Uzhhorod, Vydavnytstvo TOV Printlain, 2022;213 p. [in Ukrainian].
Malikov MV, Svatiev AV, Bohdanovska NV. Funktsionalna diahnostyka u fizychnomu vykhovanni i sporti [Functional diagnostics in physical education and sports]. Zaporizhzhia: ZNU, 2020; 227 p. [in Ukrainian].
Yeremenko VS, Kuts YuV, Mokiichuk VM, Samoilichenko OV. Statystychnyi analiz danykh vymiriuvan [Statistical analysis of measurement data]. Kyiv: NAU, 2013; 320 p. [in Ukrainian].
World Medical Association. Declaration of Helsinki: ethical principles for medical research involving human subjects [Internet]. 2008 [cited 2024 Sep 1]. Available from: https://www.wma.net/policies-post/wma-declaration-of-helsinki/
Universal declaration on bioethics and human rights [Internet]. 2005 [cited 2024 Sep 19]. Available from: https://www.unesco.org/en/legal-affairs/universal-declaration-bioethics-and-human-rights
Sokruta VM. and others. Fizychna, reabilitatsiina ta sportyvna medytsyna [Physical, rehabilitation and sports medicine]. Kramatorsk: Kashtan, 2019; 480 p. [in Ukrainian].