МОЖЛИВОСТІ МОДИФІКАЦІЇ ПІДХОДУ ДО ЛІКУВАННЯ ПАРОДОНТИТУ ВИХОДЯЧИ ІЗ ПРИНЦИПІВ P-4 МЕДИЦИНИ

Authors

  • Є.Я. Костенко
  • О.В. Савчук
  • Ю.М. Бунь

Keywords:

probiotics, oral cavity, dental status

Abstract

Depending on the different composition of the variational microbiom, diseases of the oral cavity can be manifested in different individuals by different ways, modified by the duration and features of clinical manifestations. Study of the stability and modification of microbial composition of the oral cavity under normal conditions and under the influence of various provocative factors will contribute to the development of individually-based preventive schemes in order to prevent the development of mechanisms that compromise the state of dental status. In cases of early verification of the composition of the microbiom of the oral cavity and its changes at a stage between stage 1 and stage 2 in accordance with the trajectory diagram of Loe and as a result of the implementation of individualized treatment regimens with the use of probiotics, it will be possible to reduce the trajectory A (development of middle / severe forms of pathology) and increase levels of trajectories B (with the risk of development of mild forms of pathology) and C (with the absence of pathologies) relative to previous levels.

References

Kornman, K. S., and G. W. Duff. "Personalized medicine: will dentistry ride the wave or watch from the beach?." Journal of dental research 91.7_suppl (2012): S8-S11.

Zarco, M. F., T. J. Vess, and G. S. Ginsburg. "The oral microbiome in health and disease and the potential impact on personalized dental medicine." Oral diseases 18.2 (2012): 109-120.

Korte, Dina L., and Janet Kinney. "Personalized medicine: an update of salivary biomarkers for periodontal diseases." Periodontology 2000 70.1 (2016): 26-37.

Giannobile, William V., Kenneth S. Kornman, and Ray C. Williams. "Personalized medicine enters dentistry: what might this mean for clinical practice?." The Journal of the American Dental Association144.8 (2013): 874-876.

Giannobile, William V., et al. "Patient stratification for preventive care in dentistry." Journal of dental research 92.8 (2013): 694-701.

Razzouk, Sleiman, and Omid Termechi. "Host genome, epigenome, and oral microbiome interactions: toward personalized periodontal therapy." Journal of periodontology 84.9 (2013): 1266-1271.

Otomo-Corgel, Joan, et al. "State of the science: chronic periodontitis and systemic health." Journal of Evidence-Based Dental Practice 12.3 (2012): 20-28.

Eng, G., et al. "Genome technologies and personalized dental medicine." Oral diseases 18.3 (2012): 223-235.

Anaya, Juan-Manuel, et al. "Personalized medicine. Closing the gap between knowledge and clinical practice." Autoimmunity reviews 15.8 (2016): 833-842.

Published

2023-03-06

Issue

Section

Статті